Limits of the Self: Immunology and Biological Identity

Limits of the Self: Immunology and Biological Identity[PDF / Epub] ⚣ Limits of the Self: Immunology and Biological Identity ✈ Thomas Pradeu – Heartforum.co.uk What counts as an individual in the living world What does it mean for a living thing to remain the same through time, while constantly changing These questions are the province of immunology, one of What counts as an individual in the Self: eBook ✓ the living world What does it mean for a living thing to remain the same through time, while constantly changing These questions are the province of immunology, one of the most dynamic Limits of ePUB × fields in biology Immunology answers these questions with its theory of self and nonself which has dominated the field since the s Thomas Pradeu argues that this theory is inadequate, because immune responses to self constituents and immune tolerance of the Self: ePUB ✓ of foreign entities are the rule, not the exception Instead Pradeu advances an alternative theory, the continuity theory, which offers a new way to answer the question of what triggers an immune response It also echoes the recent realization that all organisms, and not only higher vertebrates, have an immune systemPradeu s main thesis is that the self nonself theory should be abandoned, but that immunology still proves to be decisive for delineating the boundaries of the organism Articulating an evolutionary and an immunological perspective, he offers an original conception of the organism Tolerance of the fetus by the mother and of countless bacteria on the body s surfaces proves that every organism is heterogeneous, that is, made of entities of different origins In other words, every organism appears as a chimera, a mixed living thing the cohesiveness of which is ensured by the constant action of its immune systemThe Limits of the Self, will be essential reading for anyone interested in the definition of biological individuality and the understanding of the immune system.

Is a well known author, some the Self: eBook ✓ of his books are a fascination for readers like in the Limits of the Self: Immunology and Biological Identity book, this is one of the most wanted Thomas Pradeu author readers around Limits of ePUB × the world.

Limits of the Self: Immunology and Biological Identity PDF
    Limits of the Self: Immunology and Biological Identity PDF that all organisms, and not only higher vertebrates, have an immune systemPradeu s main thesis is that the self nonself theory should be abandoned, but that immunology still proves to be decisive for delineating the boundaries of the organism Articulating an evolutionary and an immunological perspective, he offers an original conception of the organism Tolerance of the fetus by the mother and of countless bacteria on the body s surfaces proves that every organism is heterogeneous, that is, made of entities of different origins In other words, every organism appears as a chimera, a mixed living thing the cohesiveness of which is ensured by the constant action of its immune systemThe Limits of the Self, will be essential reading for anyone interested in the definition of biological individuality and the understanding of the immune system."/>
  • Paperback
  • 314 pages
  • Limits of the Self: Immunology and Biological Identity
  • Thomas Pradeu
  • 02 February 2017
  • 0190869577

10 thoughts on “Limits of the Self: Immunology and Biological Identity

  1. Tomás Narvaja says:

    There is a clear reason why Pradeu won the Lakatos Award While densely informative and perhaps difficult for a reader unfamiliar with immunity, Pradeu effectively demonstrates how immunology can contribute to a biological understanding of identity, not in terms of uniqueness as the self nonself theory suggests , but in terms of individuality.In the first chapter Pradeu discusses the question of what makes the identity of a living entity and how immunology has made the study of biological ident There is a clear reason why Pradeu won the Lakatos Award While densely informative and perhaps difficult for a reader unfamiliar with immunity, Pradeu effectively demonstrates how immunology can contribute to a biological understanding of identity, not in terms of uniqueness as the self nonself theory suggests , but in terms of individuality.In the first chapter Pradeu discusses the question of what makes the identity of a living entity and how immunology has made the study of biological identity its own domain He claims the question of identity is at least two question 1 what makes the uniqueness of a living being different from other living beings including those of its own species and 2 what makes its individuality what counts as one living being, what is the unit He also pointed out that it was in 1949, that Australian virologist, Frank Macfarlane Burnet, suggested based on transplantation experiments to conceive of immunity in terms of self and nonself where recognition of the self nonself by the immune system makes the question of biological identity one to which immunology can respond Pradeu demonstrates a wide variety of claims in his book quite effectively 1 immunological self nonself theory is inadequate for a satisfying conception of biological identity 2 continuity theory permits elaboration of a satisfying conception of biological identity 3 immunology brings precise and decisive elements to bear on one particular meaning of the term, identity, that of diachronic individuality 4 immunological conception of identity applies to all organisms, showing its usefulness in dealing with the question of biological identity 5 immunology leads to precise answer of what counts as an organism the organism is not an endogenous reality, but a heterogeneous reality made up of components of different origins 6 Immunology when combined with other fields, particularly evolutionary biology, shows the organism is most highly individuated biological entity.Throughout his book, Pradeu clear defines the self nonself theory, explains its history and contextualizes its popularity He then provides a coherent, effective critique and points out various immunological phenomena, such as pregnancy, that self nonself theory largely fails to understand Pradeu proposes his alternative theory, the continuity theory He claims that an immune response is not triggered by the non self, but by a strong discontinuity in molecular patterns with which immune receptors interact In the chapter that follows, Pradeu compares his theory to other popular theories in immunology, including Polly Matzinger s Danger Theory At the end of his book, he returns to the question of what defines the organism and what immunology can say about the identity of an organism He does all this while constantly referring to specific biochemical processes in the body as evidence of his claims Pradeu concludes that 1 immunology sheds light on one meaning of identity, understood as organism s individuality where immunology s criterion of immunogenicity is itself a criterion of individuality 2 Immunology does not bring new or decisive contributions to other definitions of identity, such as when understood as uniqueness or as description of individual characteristics With regards to the question of individuality, Pradeu states that currently, evolutionary biology is the only field in biology successfully presenting a theory that unifies various types of independent facts under a single explanatory framework, can be tested empirically, and has been corroborated by data in various fields Non evolutionary fields like physiology and morphology could be useful for determining the biological individual if they were able to offer a theory, but there is none in same sense that evolutionary theory is a theory It is exactly this lack of theory that Pradeu is trying to address and does so by providing a physiological theory, specifically an immunological one He effectively demonstrates how the biochemical focus of immunology helps with precision when combined with evolutionary theory Overall, Pradeu makes a significant contribution to the philosophy of mechanistic biology or physiology and demonstrates how questions asking how raise exciting philosophical problems and can provide valuable insight to though philosophers of biology focused on the question of why such as in evolutionary biology While he critiqued various theories lack of precision, I do not recall any exact definition of what constitutes continuous interactions among immune receptors as defined by precise time intervals, what quantity of antigens is considered a very small quantity that does not provoke an immune response, what quantity is a large quantity that can paralyze the immune system, etc Additionally, I hesitated to accept his critique of claims that immunology functions as language and his critiques of anthropomorphism, especially given his generalization of the capacity of immunity If immunity is not unique to vertebrates, but is a capacity of all cells, I question why he would suggest language would be any different I would like to see an expansion of Pradeu s work that takes into consideration the philosophical insights of Vicki Kirby and her question of What If Culture Was Really Nature All Along

  2. James Hassell says:

    This book does a good job of laying out a problem, proposing an alternative, comparing it to other alternatives, and placing it in a greater context I have personally been a fan of Matzinger s danger model and am glad to read about it here I also came from a lab that focused on Tregs and the microbiome so this book was a great supplement to my background I would recommend this book to anyone interested in how biology attempts to define self.

  3. Pete says:

    This book provides an excellent history of immunology and ends with a discussion of units of selection Im not completely sure how original the discontinuity theory is but taking the authors word for it for the time being.

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